Key Differences Between Warfarin and Xarelto

If you know about the blood thinner drugs, then chances are you might have heard of the drugs named warfarin and Xarelto. Both of these substances are blood-thinning drugs and are used to cure blood clots and other diseases related to blood thickening. While warfarin has been in existence since 1954, Xarelto has been new to the market and has been introduced in 2011.

Both these drugs are often thought as the same by the people which are completely incorrect as both of them have different properties and capabilities. If you also thought the same then, here are some of the major differences between two of the most popular blood thinners Xarelto and warfarin:


Warfarin works by blocking the body’s capacity to recycle vitamin K, which is one of the most important things that causes the blood to clot. As the amount of vitamin K decreases in the body the chances of the formation of a blood clot also decrease. However, the patients provided with the drug need constant testing and monitoring to determine the dosage.

On the other hand when the xarelto it works very differently from warfarin. It doesn’t affect the vitamin K levels of the body. This means that patients using this drug aren’t required to be monitored continuously.

Warfarin and Xarelto


For stroke risk reduction and clearing of clots, the prescribed dosage of Xarelto is not more than 20mg, which is generally taken during the evening meal. However, the dosage of warfarin varies from person to person depending on the weight, age, diet, and other medications. Both of the drugs though needed to be taken after proper prescription as anoverdose can give rise to various major problems.


There are similar side effects of both the drugs that could cause bleeding. Warfarin has the risk of causing a brain hemorrhage, which can be deadly. However, the side effects of warfarin can be controlled by taking vitamin K that could neutralize its effects. On the other side, there is no known antidote for Xarelto, which means that once any problem starts it’s likely to continue. Butfortunately, the half-life of Xarelto is very short ranging from 5-8 hours, which means the effects of the drug vanish within some time.

Dietary concerns

Patients prescribed with warfarin are bound to undergo blood tests at least once a month and are needed to watch their intake of Vitamin K, an effective nutrient that can reduce the effectiveness of warfarin. Vitamin K can be found in leafy green vegetables such as spinach, kale,and chard, which is why they are needed to be skipped from the meals. On the other hand, there areno dietary issues present with Xarelto.